Reversing stem cell aging
نویسندگان
چکیده
منابع مشابه
Reversing stem cell aging
The stem cell theory of aging postulates that aging is the result of the failure of tissue specific stem cells to replenish tissues and to sustain tissue function. Stem cell functions decline with age, consistent with the degeneration and dysfunction of aging regenerative tissues. Stem cell dysfunction is associated with premature aging and evidence is emerging to suggest that stem cell manipul...
متن کاملReversing B cell aging
Age-related alterations in the cellular composition of the B lineage are a major cause of the poor antibody response to vaccination and to infectious agents among the elderly population. The mechanisms leading to these changes are poorly understood. Recently, we have shown that these changes reflect, at least in part, homeostatic pressures imposed by long-lived B cells that accumulate with agin...
متن کاملc-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy.
RATIONALE Hypoxia favors stem cell quiescence, whereas normoxia is required for stem cell activation, but whether cardiac stem cell (CSC) function is regulated by the hypoxic/normoxic state of the cell is currently unknown. OBJECTIVE A balance between hypoxic and normoxic CSCs may be present in the young heart, although this homeostatic control may be disrupted with aging. Defects in tissue o...
متن کاملStem cell aging.
202 W E summarize here the fruitful discussion that occurred on a wide variety of topics during the session on stem cell aging. Somatic Stem Cell Aging Do stem cells age; and if they do, how can these changes be reliably identifi ed? Most attendees were of the view that a decline in the function of tissue-specifi c somatic stem cells is likely to play an important role in human aging. Results f...
متن کاملHematopoietic stem cell aging.
Aging is organized in a hierarchy, in which aging of cells results in aged tissues, ultimately limiting lifespan. For organ systems that also in the adult depend on stem cells for tissue homeostasis like the hematopoietic system that forms immune cells, it is believed that aging of the stem cells strongly contributes to aging-associated dysfunction. In this review, we summarize current aspects ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.4403